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Pharmacological Effects

Author: Dr. Edward Group 05/26/2009
  • Research carried out over the last few decades has revealed the multifaceted pharmacological effects of forskolin.
  • Most of these effects have been linked to the role of forskolin as an activator of adenylate cyclase1.
  • Normally, cAMP is formed when a stimulatory hormone (e.g., epinephrine) binds to a receptor site on the cell membrane and triggers the activation of adenylate cyclase.
  • The receptors in each cell are specific to the activating hormone.
  • Forskolin appears to bypass the hormone-receptor interactions and activates adenylate cyclase. Adenylate cyclase activation induces a rise in intracellular cAMP levels2.


  1. Ammon, H.P.T. and Muller (1989) Forskolin: from an Ayurvedic Remedy to a Modern Agent Planta Medica. Vol 51, 475-476.
  2. Murray, M.T. (1995) The unique pharmacology of Coleus forskohlii. Health Counselor 7(2): 33-35.
Posted In: Coleus

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