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Lean Mass

Author: Dr. Edward Group 05/26/2009

Epidemiological studies indicate that the impact of body composition on health starts early in life.

The association between body mass and mortality in more than 100,000 U.S. women 30 to 55 years of age was evaluated. The lowest mortality rate was observed among women who weighed at least 15 percent less than the U.S. average for women of similar age and among those whose weight had been stable since early adulthood1.

In a separate study, it was found that being overweight in adolescence predicted a broad range of adverse health effects that were independent of adult weight after 55 years of follow-up2.

Role of cAMP in optimizing body composition

The biochemical mechanism of maintaining or increasing lean body mass is related to the availability of cyclic AMP.

By facilitating hormonal action, cyclic AMP may regulate the body’s thermogenic response to food, increase the body’s basic metabolic rate, and increase utilization of body fat (since thermogenesis is preferentially fueled by fatty acids derived from body fat and/or food).

These events also correspond to the buildup of lean body mass.


  1. Stevens, J. et al. (1998) The body mass index-mortality relationship in white and African American women. Obes. Res., 6(4):268-77.
  2. Must, A. (1996) Morbidity and mortality associated with elevated body weight in children and adolescents. Am. J. Clin. Nutr. 63(3 Suppl):445S-4447S
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