Safety and Toxicity

Updated: May 26 2009

The CDRI (Central Drug Research Institute) Lucknow, conducted the following studies in mice rats, rabbits, and rhesus monkeys.

acute toxicity
subacute and chronic toxicity
teratogenic and mutagenic

The results indicated that Gugulipid® extract was safe for human consumption.

A four-week, phase 1 (safety on chronic administration) study was conducted on 21 subjects with the following conditions.

9 patients with Hypertension
3 patients with IHD
2 patients with Diabetes Mellitus
3 patients with Diabetes Mellitus & Hypertension
3 patients with IHD & Hypertension
1 patient with Gout

All subjects received 400 mg of Gugulipid® three times a day (equivalent to 25 mg of guggulsterones). No adverse effects were reported for liver function, blood glucose, blood urea levels, hematological parameters, or electrocardiogram results. Only one patient complained of epigastric fullness three days after Gugulipid® administration that was controlled by antacids.

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