1. Open Field Study to Evaluate Gugulipid® in the Treatment of Dyslipidemias – Department of Veterans Affairs Medical Center (Arizona)

The purpose of this study is to investigate the effect of Gugulipid® on serum lipids (i.e. cholesterol, LDL, HDL, triglycerides) in individuals with dyslipidemias. All individuals are volunteers who have serum cholesterol levels > 200 mg/dL. Serum cholesterol levels and the levels of other parameters are measured prior to and after treatment with Gugulipid®.

2. IND Study #59, 172 – Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of Gugulipid® in Americans with Hypercholesterolemia – University of Pennsylvania.

The purpose of this study is to evaluate the efficacy and safety of Gugulipid® in Americans with dyslipidemias. The participants of the study are volunteers, 18 years and older, who have LDL levels between 130-190 mg/dL and triglycerides less than 400 mg/dL. The safety of the study will be measured by self-reported adverse events. In addition hematological and blood biochemistry parameters will be assessed throughout the study to monitor safety and efficacy. The efficacy of Gugulipid® will be measured as a percent change from baseline in total cholesterol, LDL, HDL, and triglycerides in Gugulipid® versus placebo groups.