Pharmacological Effects

Updated: May 26 2009

Research carried out over the last few decades has revealed the multifaceted pharmacological effects of forskolin.
Most of these effects have been linked to the role of forskolin as an activator of adenylate cyclase1.
Normally, cAMP is formed when a stimulatory hormone (e.g., epinephrine) binds to a receptor site on the cell membrane and triggers the activation of adenylate cyclase.
The receptors in each cell are specific to the activating hormone.
Forskolin appears to bypass the hormone-receptor interactions and activates adenylate cyclase. Adenylate cyclase activation induces a rise in intracellular cAMP levels2.

References

Ammon, H.P.T. and Muller (1989) Forskolin: from an Ayurvedic Remedy to a Modern Agent Planta Medica. Vol 51, 475-476.
Murray, M.T. (1995) The unique pharmacology of Coleus forskohlii. Health Counselor 7(2): 33-35.

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