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Curcumin

Author: Dr. Edward Group 05/26/2009
 

The objective of this study was to evaluate the bioavailability of curcumin co-administered with Bioperine® in animals and human volunteers. Curcumin is a phenolic phytochemical obtained from turmeric ( Curcuma longa L). It has been scientifically researched that Curcumin has effective therapeutic outcome acting as an antioxidant, anti-inflammatory, antispasmodic, anticoagulant, anticarcinogenic, immunomodulatory activities and even in wound healing. It has been found that the therapeutic effectiveness of curcumin is often limited due to its poor absorption from the GI tract. When taken orally only traces appear in the blood whereas most of the dose is excreted though the feces.

Piperine was found to enhance the bioavailability of Curcumin both in preclinical studies and in studies on human volunteers.

BIOAVAILABILITY STUDIES: CURCUMIN & BIOPERINE®

Pharmacokinetic parameters (mean ± SEM) of oral curcumin 2g/kg alone and in combination with Bioperine® 20 mg/kg in rats (n= 6).

Parameters
Curcumin alone
2 g/kg
Curcumin + Bioperine®
2g/kg + 20mg/kg
Cmax (mg/ml)
1.35 ± 0.23
1.80 ± 0.16
Tmax (h)
0.83 ± 0.05
1.29 ± 0.23″
t1/2(a) (h)
0.31 ± 0.07
0.47 ± 0.03
t1/2(el) (h)
1.70 ± 0.58
1.05 ± 0.18″
AUC(0 – tn) (mg/h/ml)
2.36 ± 0.28
3.64 ± 0.31
Vd (L/kg)
1366.00 ± 248.70
782.90 ± 193.90
Cl(L/h)
713.00 ± 12.00
495.90 ± 37.08″
  • “P < 0.02: Statistical significance by Student’s “t” test
  • Cmax: Maximum serum concentration
  • Tmax: Time to reach maximal serum concentration
  • t1/2(a): Absorption half-life
  • t1/2(el): Elimination half-life
  • AUC(0 – tn): Area under the concentration time curve
  • Vd: Volume of distribution
  • Cl: Total clearance

EFFECT OF BIOPERINE® ON SERUM CONCENTRATIONS OF CURCUMIN IN RATS.

Pic 1

BIOAVAILABILITY STUDIES – CURCUMIN & BIOPERINE

Pharmacokinetic parameters (mean + SEM) of oral curcumin 2 g alone and in combination with Bioperine® 20 mg in normal healthy volunteers (n=8).

Parameters
Curcumin alone
2 g
Curcumin+Bioperine®
2g+20mg
Cmax (mg/ml)
0.006 ± 0.005
0.18 ± 0.03
Tmax (h)
1
0.69 ± 0.07
t1/2(a) (h)
0.11 ± 0.02
t1/2(el) (h)
0.41 ± 0.17
AUC(0 – tn) (mg/h/ml)
0.004
0.08 ± 0.01
Vd (L/kg)
202.60 ± 78.94
Cl(L/h)
7.33 ± 1.25
F (Relative bioavailablility)
2000%

EFFECT OF BIOPERINE® ON SERUM CONCENTRATIONS OF CURCUMIN IN HUMAN VOLUNTEERS

Pic 3

Posted In: Bioperine

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