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Co Q10

Author: Dr. Edward Group 05/26/2009
 

Co Q10 – PHARMACOKINETIC EVALUATION unique difficulties:

  • Slow absorption from GI tract
  • Enterohepatic recycling
  • Endogenous Co Q10 production

Co Q10 – PHARMACOKINETIC MODEL

Graph 7

X0 : Gastrointestinal compartment
X1 : Plasma chylomicrons and the tissues where rapid distribution can take place
X2 : Liver
X3 : VLDL and tissues which are rapidly accessible to Co Q10

Plasma concentration of Co Q10 = X1 + X3

Pharmacokinetics of Coenzyme Q10. The increase in blood levels following a single oral intake of Coenzyme Q10 (90 mg) with and without Bioperine® (5mg)

Graph 8
Time of assay after a single dose administration of Coenzyme Q10

Absolute change in serum Coenzyme Q10 after 14 days supplementation of Coenzyme Q10 (90mg/day) with and without Bioperine® (5mg/day)

Graph 9

Graph 11

Effect of Bioperine® on serum CoQ10 levels during a 21 day supplementation trial.

Mean serum CoQ10 AUC values following supplementation of 120 mg of CoQ10 with and without 5 mg of Bioperine®

Graph 10

Posted In: Bioperine

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