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Beta Carotene

Author: Dr. Edward Group 05/26/2009
 
Double-Blind, Crossover Design *
Volunteer #’s Phase I Phase II
# 1 thru # 6 β-Carotene+
placebo
β-Carotene+
Bioperine®
# 7 thru # 12 β-Carotene+
Bioperine®
β-Carotene+
placebo
* Phase I & Phase II supplementation periods occurred 12 weeks apart.
Serum Vitamin A Levels (mg/dl)
Treatment Baseline Day 14 Change
bβ-Carotene+
placebo
66.0 + 11.5 65.1 + 10.2 -0.9 + 2.4
β-Carotene+
Bioperine®
65.2 + 11.9 65.0 + 10.6 -0.2 + 2.1
Comparisons (baseline vs. Day 14, placebo vs. Bioperine® at Day 14, placebo vs. Bioperine® change at Day 14) indicated no statistically significant differences.
Serum β-Carotene levels (μg/dl)
Treatment Baseline Day 14 Change
bβ-Carotene+
placebo
16.3 + 2.6 47.2 + 6.4 30.9 + 5.4
β-Carotene+
Bioperine®
16.0 + 3.1 65.8 + 9.7 49.8 + 9.6
Comparisons (baseline vs. day 14, placebo vs. Bioperine®at Day 14, placebo vs. Bioperine® change at Day 14) indicated statistically significant differences (all p<0.0001)
Serum β-Carotene AUC Levels at Day 14
Treatment AUC
ug/dl/day
% Difference
β-Carotene+
placebo
272.0 + 47.6
β-Carotene+
Bioperine®
435.2 + 74.2 160
Comparison of AUC indicated a statistically significant difference (p<0.0001).

 

Graph 2

Figure 1. Effect of Bioperine® on the mean serum β-Carotene levels during a 14 day supplementation trial.

Graph 62

Summary

The relative bioavailability of β-Carotene is improved during a 14 day supplementation trail when it is ingested with Bioperine®

Posted In: Bioperine

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