Research And Studies

Updated: May 21 2009

Most of the research on Citrus aurantium has been conducted using Advantra Z®. Below is a compilation of some of that research:

Efficacy Studies

Aug 2003		Scientific Difference Between Citrus aurantium and Ephedra, Jones
2002		Journal of Medicine Study: Citrus aurantium as a Thermogenic, Weight-Reduction Replacement for Ephedra: An Overview – Preuss/DeFerndinando
Mar 1999		Twin Lab Study – Effects of Citrus aurantium (Advantra Z®), Caffeine and St. John’s Wort on Body Fat Loss, Lipid Levels, and Mood States in Overweight Healthy Adults, published in Current Therapeutic Research, Colker/Kalman
1999		McGill Study – Thermic Effect of Citrus aurantium on Obese Subjects, Pathak/Gougeon
1999		McGill Study – Thermogenic Effect of Citrus aurantium in Humans, Hedrei/Gougeon

Safety/Toxicity Studies

2005		Hemodynamic effects of ephedra-free weight-loss supplements in humans
2001		Seville Orange Juice: Synephrine Content in Citrus aurantium and Cardiovascular Effects in Normotensive Adults, published in Journal of Clinical Pharmacology, Penzak/Jann
Nov 1997		An Acute Oral Toxicity Study (LD50) of Advantra Z® in Rats, Douds

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